The second exhibition day of "Analitika Expo 2025" has ended. More than 230 participants continue to demonstrate new products and proven solutions for laboratory equipment and chemical reagents at their stands.

Results of events in the Lecture Hall

Seminar "Current issues of competence of accredited analytical laboratories. Management of non-conforming work"

The event partner is AAC "Analytics".

Ivan Vladimirovich Boldyrev spoke on the topic of "Nonconformities. Identification and recording" . The expert presented a nonconformity recording sheet, which includes recording of the nonconformity with the date, employee's name and description of the nonconformity. The nonconformity review stage includes the options "Accepted for review/Not a nonconformity", it should also indicate the nature of the nonconformity with an indication of the established requirement. At the same time, the sheet should also have the signature of the person responsible for identifying deviations from the management system or from the procedures for implementing laboratory activities with the date. The decision on nonconformity may be as follows:

• Suspend testing (specify which ones and specify conditions for resumption)

• Review (cancel) the results of work performed previously (specify which, specify the deadline and the person responsible)

• Make a correction (eliminate the discrepancy, indicating how, when and who is responsible)

• Perform corrective actions - record in the corrective action log

The decision must be confirmed by the signature of the person responsible for initiating measures to prevent or minimize such deviations with the date of the decision and the signature of the person responsible for improving the management system with the date of completion of the review.

Olga Aleksandrovna Eroshina gave a presentation on "The Place of Nonconformity Management in the Process Approach" . The speaker presented the concept of the process approach according to GOST ISO/IEC 17025-2019. The laboratory's competence consists of two equivalent principles:

• Technical ability to obtain reliable results

• A system that ensures impartiality and reliability at all times

The speaker then presented a schematic structure of laboratory activities taking into account the process approach. According to the expert, "non-conformities may arise at any stage of work, and therefore processes must be described correctly ." Non-conformity processing includes 3 stages: non-conformity detection, registration and analysis of causes (corrective actions) and new practices. Olga Eroshina also noted that non-conformity elimination may be expressed in order refusal, changes in the management system, resumption of work, while an important step will remain the analysis of the causes of non-conformity.

"Formulation of inconsistencies during internal audits" is the topic of the report by Vera Ivanovna Sheveleva . According to the expert, a management system is needed to organize the work of the laboratory and obtain a reliable result. Detection of inconsistencies within the framework of routine work is a sign that the management system works. At the same time, it is desirable to identify them before the customer does so. Then the speaker presented the principles of formulating inconsistencies.

Svetlana Sergeevna Badulina spoke about corrective actions using the example of the experience of implementing the procedure at ZAO ROSA . The expert noted the difference between the terms "non-conforming work" and "non-compliance" and presented the procedure for developing corrective measures using the example of ZAO ROSA. Identification of non-conforming work includes 3 levels:

• Level 1 – external audits, customer complaints, internal audits, management analysis, etc.

• Level 2 - supervision of personnel, verification of protocols, verification of the correct application of the methodology

• Level 3 - observations of the performer, checks of records, quality control

The speaker also presented the rules for formulating non-conforming work and the sources of non-conforming work, including methods, equipment, materials, personnel and the environment. In conclusion, Svetlana Badulina shared an example of corrective measures at the enterprise ZAO ROSA.

Seminar "Proficiency Testing Program or ITP. Opportunities and Justification of Choice. New Directions"

Partner - International Scientific Research Center MSI.

Alla Vladimirovna Kartashova , Head of the Analytical Center of ROSA JSC, spoke on the topic "Sampling as a new direction of proficiency testing programs" . According to the ILAC policy P9:01/2024, proficiency testing should be carried out in the main areas of the laboratory's activities, including sampling. The expert commented on the term "interlaboratory comparisons" and Appendix A of the ISO/IEC 17043:2023 standard. Speaking about checking the correctness of sampling, the expert highlighted the verification of records, knowledge and verification of compliance with the requirements for equipment, reagents and materials. Speaking about interlaboratory comparisons, the speaker drew attention to the following points:

• Two or more laboratories

• Conditions as close to real as possible

• Equal conditions for all participants

• Verification plan for comparisons

• Performance evaluation criteria

• Report with results of all participants

According to Alla Kartashova, when developing a plan, it is necessary to take into account the properties of the object, the place and point of collection, the objectives of the research and its type, as well as the indicators being determined. The expert identified the following as the main areas for improvement:

• A more in-depth study of the provisions of the documents regulating sampling

• Training of samplers with practical exercises and knowledge testing

• Improving the sampling order acceptance system

Anna Sergeevna Zhuk , expert on accreditation of testing laboratories of the Federal Accreditation Service, lecturer of the training center of OOO CC Znanie, presented the algorithm of actions of a testing laboratory in accordance with the requirements of the standard GOST ISO/IEC 17025-019 . The speaker drew attention to paragraphs 7 "Process requirements" and 8 "Management system requirements" of the standard, as well as document CM No. 03.1-1.0008. The expert noted that upon receipt of unsatisfactory results of participation in the PC and/or MSI, different from the PC, the laboratory must establish the cause of unsuccessful participation and develop adequate corrective measures. The effectiveness of corrective measures must be confirmed by repeated participation of the laboratory in the PC and/or MSI, different from the PC. Anna Zhuk also presented an algorithm of actions to find the causes of non-compliance:

1. Suspend issuance of results in this area of ​​the TC
2. Determine the reason for obtaining a questionable or unsatisfactory result
3. According to the methodology established in the laboratory management system, determine the reasons for the discrepancy that has arisen (the probability of a questionable result is 5%, the probability of an unsatisfactory result is 0.3%)

In conclusion, the speaker presented a method for finding the reasons for the emergence of discrepancies.

Seminar "Non-laboratory analysis"

Partner — NAAC RAS. The event was moderated by Elena Igorevna Morosanova, Doctor of Chemical Sciences, Professor. Lomonosov Moscow State University, Faculty of Chemistry, Department of Analytical Chemistry.

Boris Borisovich Dzantiev , D.Sc. (Chemistry), Prof., A.N. Bakh Institute of Biochemistry presented a report "Test systems for rapid non-laboratory diagnostics: new solutions and opportunities" . The expert spoke about the areas of application of non-laboratory tests (soil monitoring, food quality control, water control, disease biomarkers, etc.). The speaker also commented on the features of immunochromatographic test systems (ICTS), noting that the main part of the market is accounted for by medical diagnostics. Developing areas of ICTS include veterinary medicine, agriculture, and biosafety. Boris Dzantiev also identified a number of tasks for improving ICTS and spoke about portable detectors and communication devices (for example, attachments for recording tests, applying samples, and aging background signals).

Sergey Viktorovich Kholodkevich , D.Sc. (Eng.), Prof., Chief Researcher, St. Petersburg Research Center for Environmental Safety of the Russian Academy of Sciences, Head of the Laboratory of Bioelectronic Methods of Geoecological Monitoring, spoke about the experience of screening studies of the “ health” of water ecosystems based on diagnostics of the state of bivalve mollusks living in them using the functional load method. Currently, significant attention in most developed countries is paid to the development of instrumental, instrumental biological early warning systems (BEWS) on the level of toxicological danger of water as a habitat for aquatic organisms. The expert spoke in more detail about two types of technologies being developed for monitoring the general toxicity of water, based on the use of the BioArgus bioelectronic system: for the tasks of continuous diagnostics of acute water toxicity and for diagnostics of the biological consequences of chronic water pollution. Sergey Kholodkevich shared the methodology and results of testing the adaptive capacity of mollusks in field assessments of the ecological state of marine and freshwater areas based on an analysis of cardiac activity and the behavior of bottom invertebrates.

Andrey Yuryevich Bogomolov , Samara State Technical University, Head of the Department of Analytical and Physical Chemistry, Chief Researcher, National Research University Higher School of Economics, Faculty of Biology and Biotechnology, International Laboratory of Microphysiological Systems spoke on the topic of "LED Multisensory Systems" . The expert spoke about the prerequisites for the emergence of non-laboratory analysis and optical multisensory systems. The speaker also gave examples of the development and application of OMS for various areas, such as the food industry, pharmaceuticals and others. Andrey Bogomolov also shared his opinion on what changes await analytical chemistry: for example, the development of non-laboratory analysis will not stop at industrial tasks, and chemical analysis will become a mass phenomenon with new tasks. At the same time, optical systems can play an important role in these changes, due to their availability, adaptability and miniature size.

Results of events at the SMARTLABFORUM site

The partner of the SMARTLABFORUM platform is GenoLab.

Practical session "Analytical equipment and measurement accuracy in the environmental monitoring system"

Partner — Yerba-Eco Consulting. The moderator was Georgy Aleksandrovich Sambursky, Deputy Director of RAVV, Professor of the Russian Chemical Technology University, Chairman of TC 343 "Water Quality" of Rosstandart.

Narine Gareginovna Oganyan , Federal State Unitary Enterprise "All-Russian Research Institute of Physical, Technical and Radiotechnical Measurements", spoke about the role of metrology in issues of pollution monitoring and control . The speaker presented a brief historical background on the important stages of metrology development, and also shared examples of metrology laboratories in different countries.

Evgeny Alekseevich Pankov , CEO of IMC Group LLC , spoke on the topic of "Automatic monitoring of industrial emissions: experience of implementing modern gas analysis equipment" . The speaker mentioned the automatic industrial emission control systems CEMS-2000T, CEMS-2000A and presented examples of implementation.

Sambursky Georgy Aleksandrovich , Deputy Director of RAVV, Professor of RCTU, Chairman of TC 343 "Water Quality" of Rosstandart, drew attention to issues for monitoring aquatic environments . The expert noted that background monitoring is carried out by Roshydromet, Rosprirodnadzor - emission monitoring, and the water user - current activities. The speaker also presented the developed standard with indicators and quality classes of a water body, in which the water quality classes were revised (5 classes from very clean to dirty water).

The topic of "Development of mass spectrometric equipment to ensure analytical control of technological processes" was presented by the chief designer of the R&D "Mass Spectrometer" Igor Alekseevich Popov . The speaker told about the operating principle of the mass spectrometric analyzer, the device system and software, as well as general technical characteristics. The expert also noted a promising project for the creation of mass spectrometers - a high-resolution gas chromatograph-mass spectrometer based on Kingdon traps, the launch of which is planned after 2025.

Seminar "Analytical Chemistry of Microplastics: Challenges, Problems and Solutions"

The event partner is the NAAC RAS. The moderator was Mikhail Alekseevich Proskurnin, Prof., D.Sc. (Chemistry), Lomonosov Moscow State University, Faculty of Chemistry. Mikhail Alekseevich Proskurnin also spoke on the topic "Microplastic Pollution: Scientific Objectives and Problems of Analytical Chemistry" . The term "microplastic" was first used in an article by Richard Thompson in 2004. In 2021, the problem of microplastic was included in the UN Environment Program as part of the overall problem of plastic pollution. It is noted that the annual release of microplastic into the environment is 10-50 million tons. Among the problems and prospects of the issue related to microplastic, Mikhail Proskurnin highlights the following:

• Increasing the share of in vivo analysis

• Development of a methodology for the analysis of submicroplastics

• Methodology of sample preparation

• Joint analysis of micro-, submicro- and nanoplastics

• Formation of a unified platform of analysis methods

• A turn to the issue of measurement accuracy and uncertainty

According to the expert, the share of publications on microplastics in analytical sciences is about 5-6%. According to the speaker, “Microplastics are a serious and complex problem that requires very balanced solutions . ”

Andrey Vladimirovich Pirogov , prof. D.Sc. (Chemistry), M.V. Lomonosov Moscow State University, Faculty of Chemistry, presented a report "Objects, approaches and solutions in chemical analysis of microplastics" . Among the features of nanoplastics and emerging analytical problems, the expert highlights:

• Problems of capture

• Non-standardized sample preparation

• Difficulty in local analysis/identification or shape determination

• There are virtually no calibration standards and other

The expert attributes the contamination factor (special clothing and masks made of polymeric materials, plastic tools, etc.) to the causes of false results when working with microplastics. Andrey Pirogov also commented on the advantages and disadvantages of microplastic and nanoplastic analysis methods, including:

• Microscopy - good visualization and counting of the number and shape of particles (disadvantages - optics are insufficient for nanoplastics, labor-intensive and time-consuming)

• Spectroscopy - work with objects < 1 µm, information on composition, locality of information (disadvantages - cost, limited set of recognizable polymers)

• Pyrolytic chromatography - identification reliability, multicomponent (disadvantages - cost, only volumetric analysis, no correlation between the composition and shape of objects)